Controlled study on amisulpride in the treatment of the negative symptoms of schizophrenia

Objective To study the effectiveness of the negative symptoms of schizophrenia patients treated with amisulpride.Methods 72 patients of schizophrenia wererandomly assigned to amisulpride group( 36 cases) and risperidone group( 36 cases). The efficacy were assessed by Positive and Negative Syndrome Scale( PANSS),adverse side effect were evaluated with Treatment Emergent Symptom Scale( TESS). Results After 8- week treatment,the scores of PANSS in both groups decreased significantly compared to the baseline( P 0. 01). The effective rate was 88. 9% and 86. 1%. No significant difference was found in effect between the two groups( P 0. 05). But the scores of negative symptom in amisulpride group decreased significantly compared to the risperidone group,and had significant difference( P 0. 05). By the end of the treatment,no significant difference was found in TESS between the two groups( P 0. 05). Conclusion Amisulpride is as effective as risperidone for the treatment of positive symptoms of schizophrenia patients,but it' s better than that of risperidone in the treatment of the negative symptoms.