Effects of preemptive analgesia with flurbiprofen axetil and dezocine on postoperative pain and stress response in patients with gastric cancer

Objective To explore the effects of preemptive analgesia with flurbiprofen axetil and dezocine on postoperative pain and stress response in patients with gastric cancer. Methods Sixty-four patients with gastric cancer were selected and divided into group D (32 cases) and group FD (32 cases) according to the random digital table method. The patients in group FD were preemptively given dezocine, and the group D were given flurbiprofen axetil with dezocine preemptively. Fentanyl patient-controlled intravenous analgesia was given in the two groups after operation. VAS and cortisol, epinephrine, norepinephrine, lipid peroxide levels at different time and adverse reactions were observed and compared. Results VAS in group D at 4, 8, 12 h after the operation were higher than that in group FD, which was statistically significant (P 0.05) , but significantly increased at 8 h after the operation (P 0.05) , which were significantly increased at 1d and 3d after operation (P 0.05) , but it was significantly higher in group FD than that before the operation (P<0.05) . The incidence of adverse reactions in group D was 6.2%, which was significantly lower than that of 31.2% in group FD (P<0.05) . Conclusion Preemptive analgesia with flurbiprofen axetil and dezocine can effectively reduce the patients' pain level, reduce the stress response and adverse reactions. Key words: Flurbiprofen axetil; Analgesics, opioid; Preemptive analgesia; Stomach neoplasms; Pain, postoperative; Stress response