Yun-shu Qiu
Abstract
目的:检测慢性粒细胞白血病残留细胞.方法:应用RT-PCR方法对20例(其中6例为异基因骨髓移植术后)慢性粒细胞白血病患者进行血或骨髓的bcr/abl mRNA检测.结果:20例初发时Ph染色体阴性1例,阳性19例,20例均检出bcr/abl基因扩增产物.全部病例进行连续性监测发现,6例异基因骨髓移植患者5例最终Ph染色体及bcr/abl基因转阴,1例持续阳性并检出两类(168 bp或93 bp)bcr/abl基因.结论:RT-PCR是当前检测慢性粒细胞白血病残留细胞比较可靠的方法.
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目的:检测慢性粒细胞白血病残留细胞.方法:应用RT-PCR方法对20例(其中6例为异基因骨髓移植术后)慢性粒细胞白血病患者进行血或骨髓的bcr/abl mRNA检测.结果:20例初发时Ph染色体阴性1例,阳性19例,20例均检出bcr/abl基因扩增产物.全部病例进行连续性监测发现,6例异基因骨髓移植患者5例最终Ph染色体及bcr/abl基因转阴,1例持续阳性并检出两类(168 bp或93 bp)bcr/abl基因.结论:RT-PCR是当前检测慢性粒细胞白血病残留细胞比较可靠的方法.
Key concepts: Myelocytic leukemia, Chronic lymphocytic leukemia, Minimal residual disease, Leukemia, Medicine, Biology, Virology, Immunology