Clinical effects of seretide inhalation combined with tiotropium on COPD in stable phase

Objective To observe the clinical effect of seretide inhalation combined with tiotropium on chronic obstructive pulmonary disease(COPD) in stable phase and its effect on TNF-α Methods Sixty patients with COPD in stable phase were randomly divided into two groups:the control group (n =30) and the treatment group (n =30).The control group was treated with inhalation of seretide (50/500 μg,bid),while the treatment group was treated with inhalation of seretide plus tiotropium (18 μg,qd).Meanwhile,patients in both groups received conventional anti-infective,anti-asthmatic and symptomatic treatment,and the lung function was detected before and after treatment; and serum TNF-α was measured by ELISA before and after treatment.Results The pulmonary function of COPD in stable phase obviously improved,the expression of TNF-α decreased in treatment group.There were significant differences compared with the control group (P ＜ 0.05).Conclusions Inhalation of seretide plus tiotropium could improve the pulmonary function and reduce the expression of TNF-α,and was more effective than seretide monotherapy. Key words: Inhalation of seretide ;  Tiotropium ;  Chronic obstructive pulmonary disease ;  Tumor necrosis factor-α