Relationship between expression of VEGF and COX-2 in breast cancer

Objective To discuss the expression of VEGF and COX-2 in breast cancer and their correlation with Clinical relationships. Methods With Elivision immunohistochemistry, the expression of VEGF and COX-2 was evaluated in 60 samples with primary breast cancer, and it was determined that the correlation of their expression and the clinical features including age, tumor size, clinical TNM staging,pathological grading,armpit lymph node metastasis and prognosis. Results The expression of VEGF had close correlation with tumor size, the clinical TNM staging, pathological grading, and armpit lymph node metastasis (P ＜0.05), but had no correlation with age. The expression of COX-2 had close correlation with the clinical TNM staging pathological grading, and armpit lymph node metastasis (P ＜0.05), but had no correlation with age and tumor size. The expression of VEGF had positive correlation with that of COX-2 (r =0.2615, P ＜0.05);In the death group, the expression of VEGF and COX-2 was significantly higher than the survival group (P ＜0.05). Conclusion The up-regulated expression of VEGF and COX-2 closely correlated with tumor take place, evolution, metastasis and soake of breast carcinoma. The expression of COX-2 had positive correlation with that of VEGF. Combined detection would be helpful in screening the patients of breast cancer with high risks of recurrence and metastasis, judge the prognosis, so it is good for further treatment. Key words: Breast neoplasms;  Vascular endothelial growth factors;  Cycloosygenase 2