Study on the correlation between blood flow parameters and cerebral infarction in brain artery stenosis

Objective To evaluate the correlation of hemodynamic parameters and blood pressure with cerebral infarction in elderly patients with stenosis. Methods 216 elderly patients with transient ischemic attack(TIA)caused by cerebral stenosis were collected and divided into the cerebral infarction group and the control group.Differences in hemodynamic parameters and blood pressure between the two groups and the correlation between the parameters and cerebral infarction were analyzed.Receiver operating characteristic(ROC)curves were used to analyze the specificity, sensitivity and threshold of each parameter under different degrees of stenosis. Results After adjusting for the well-known associated factors, the occurrence of cerebral infarction was negatively correlated with systolic peak velocity(Vs), end diastolic velocity(Vd)and mean blood flow velocity(Vm), and positively correlated with diastolic blood pressure(r=-0.445、-0.420、-0.459、0.292, P 92.3 mmHg(1 mmHg=0.133 kPa); Vs≤185.8, Vd≤83.6, Vm≤123.7 cm/s, and diastolic blood pressure >104.5 mmHg; Vs≤198.6, Vd≤121.1, Vm≤137.5 cm/s, and diastolic blood pressure >109.6 mmHg, respectively. Conclusions There is a correlation between the blood flow parameters and elderly cerebral infarction.Based on the degree of cerebral arterial stenosis, the risk of cerebral infarction occurrence is greater with decreased blood flow velocity and increased diastolic blood pressure. Key words: Ischemic attack, transient; Brain infarction; Hemodynamics