2018•国际医药卫生导报Requires access
Effect of recombinant human brain natriuretic peptide on serum NT-proBNP concentration and cardiac function in patients with chronic heart failure
Guangjian Zhang
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Abstract
Objective
To explore the effect of recombinant human brain natriuretic peptide on the concentration of serum N-terminal B type natriuretic peptide (NT-proBNP) and cardiac function in patients with chronic heart failure.
Methods
60 patients with chronic heart failure treated at our hospital from January, 2014 to February, 2017 were selected and randomly divided into an observation group and a control group, 30 cases for each group. The control group were treated with conventional drugs; in addition, the observation group were treated with recombinant human brain natriuretic peptide. The treatment effect, cardiac function, and serum indicators were compared between these two groups.
Results
After the treatment, the total efficacy and LVEF were significantly higher and the LVEDs, LVEDd, IL-6, and NT-proBNP were significantly lower in the observation group than in the control group, with statistical differences (P < 0.05). No severe headache, nausea, and other symptoms were not found during treatment in these two groups.
Conclusion
Recombinant human brain natriuretic peptide for patients with chronic heart failure can improve the clinical treatment effect, serum indexes, and cardiac function.
Key words:
Chronic heart failure; Recombinant human brain natriuretic peptide; Serum NT-proBNP concentration; Cardiac function