2009•国际外科学杂志Requires access
Immune regulative mechanism of indoleamine 2,3-dioxygenase and its effects in transplantation tolerance and tumor escape
Mingzhe Weng, Junming Xu
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Abstract
Indoleamine 2,3-dioxygenase(IDO)is an intracellular hemeprotein enzyme which catalyses the essential amino acid tryptophan.Accumulating evidences have demonstrated that tryptophan depletion and its toxic metabolites can suppress local allogeneic T cell proliferation and lead to apoptosis.With the study of the mechanism of immune regulation of IDO goes further,it have emerged as a proming enzyme in organ transplantation and tumor treatment.We reviewed in the article the immune regulative mechanism of IDO and its effects in transplantation tolerance and tumor escape.
Key words:
indoleamine 2,3-dioxygenase; transplantation tolerance; tumor escape