2009•Medical RecapitulateRequires access
Indoleamine 2,3-dioxygenase and Tumor Immune Tolerance
Yan Mao-li
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Abstract
Tumor immune tolerance is a process of acquired immune response involving many mechanisms.Indoleamine 2,3-dioxygenase(IDO)is the rate-limiting enzyme in the kynurenine pathway of catabolism.IDO induces tumor immune tolerance hemisphere,which can inhibit T cell proliferation/activation,via inducing tryptohan depletion environment,cytotoxicity of metabolite and modulating Tregs.The inhibitors of IDO may provide a prosperous therapeutic method for tumors.