2008•中国综合临床Requires access
Expression of cox-2 in human colorectal carcinoma and its clinical significance
Weiguo Xu, Ji-ning Song, Xiao-qing Yang, Shi-zhu Hao, Chan-chan Hu, Ming Li, Chuntao Wu, Hongcheng Zhu, Ruiwei Li, Zhao Guang-ming
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Abstract
Objective To investigate whether cyclooxygenase-2(COX-2)expression are related to the clinicopathological features,and to microvessel density(MVD).Methods COX-2 expressions were detected in 45colorectal carcinoma samples by immunostaining.MVD was evaluated with the specific antibody CD105.Quantitationof COX-2 mRNA was performed by RT-PCR in 45 specimens of colorectal carcinoma.Results The expressions of COX-2 mRNA and protein were significant variation among lymphatic metastasis,high Dukes stages and grade of differation(P＜0.05);Increased value of MVD were significant variation among lymphatic metastasis,high Dukes stage and depth of tumor invasion(P＜0.05).Both the overexpression of COX-2 protein and mRNA was positively correlated with the value of MVD(P＜0.05).Conclusion COX-2 plays an important role in the development of colorectal carcinoma.COX-2 may up-regulate the value of MVD,which induces angiogenesis and accordingly contributes to metastasis.
Key words:
Colorectal carcinoma; COX-2; CD105; MVD; Angiogenesis