2016•Zhongguo jiceng yiyaoRequires access
The application effect of insulin aspart alone or in combination with metformin to treat diabetes
Wenyun Wang, Lingyun Wu
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Abstract
Objective
To study the application effect of insulin aspart alone or in combination with metformin to treat diabetes.
Methods
80 patients with diabetes from February 2014 to February 2015 were studied.They were randomly divided into observation group and control group, 40 cases in each group.The observation group was given insulin aspart therapy combined with metformin hydrochloride tablets.The control group was treated with insulin aspart.The blood glucose levels, insulin dosage were recorded, the incidence of hypoglycemia was analyzed in the two groups.
Results
After treatment, the blood glucose levels in the two groups were lower than before treatment, the decrease of the observation group was more significant than the control group, the difference was statistically significant (P 0.05), the highest blood glucose value of the observation group was lower than the control group [(7.3±1.1)mmol/L vs (8.5±1.8)mmol/L)], there was statistically significant difference (t=3.597 8, P=0.000 2). The average blood glucose level of the observation group was also shorter than the control group, there was statistically significant difference (t=10.880 3, P=0.000 2). After treatment, NIHSS scores of the two groups were decreased, NIHSS score reduce the magnitude of the observation after treatment was significantly higher than the control group (4.33±0.82) vs.(5.24±1.25), there was significant difference(t=3.849 8, P=0.000 2). The effect of improving lipid levels observed were significantly better than the control group, the difference was statistically significant (P<0.05).
Conclusion
Combination of insulin aspart and metformin hydrochloride tablets in the treatment of patients with diabetes to control blood sugar levels is better than the effect of single treatment with insulin aspart, insulin aspart therapy combined with metformin hydrochloride tablets in patients with diabetes can reduce postprandial 2h, fasting glucose, reduce the incidence of hypoglycemia, it should be popularized and used in the clinical.
Key words:
Diabetes; Insulin aspart; Metformin hydrochloride