2020•Chinese journal of plastic surgeryRequires access

Research progress of aging-related diseases treatment of human umbilical cord mesenchymal stem cells

Shudan Zheng, Mengsen Li, Hua Liu, Yabing Dong, Shimeng Cheng, 良樹鷹津, Zhifei Liu, Ningwen Zhu

Abstract

With the development of stem cell transplantation technology, anti-aging treatment or treatment of degenerative diseases through the input of stem cells has become a research hotspot. Human umbilical cord mesenchymal stem cells (HUCMSCs) are unique precursor cells which are derived from Wharton’s jelly and the perivascular tissue of umbilical cord. They have been identified to be self-renewal and multi-differentiation potential. Currently, a large number of scientific studies have shown that HUCMSCs can achieve anti-aging effects by regenerating and repairing senescent cells, tissues and organs. This article reviews the research advances in biological characteristics, tissue regeneration and repair mechanisms, and anti-aging treatment mechanisms of HUCMSCs in detail. Besides, the current status of preclinical research on HUCMSCs is summarized, suggesting that HUCMSCs is a type of stem cell therapy with good potential and value. Key words: Umbilical cord; Mesenchymal stem cells; Stem cell transplantation; Anti-aging

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Key concepts: Mesenchymal stem cell, Stem cell, Umbilical cord, Wharton's jelly, Transplantation, Stem-cell therapy, Regenerative medicine, Regeneration (biology)