Effect of different doses of rosuvastatin Calcium in the treatment of coronary heart disease complicated with hyperlipemia and its influence on blood lipid level

Objective To investigate the effect of different doses of rosuvastatin Calcium in the treatment of coronary heart disease complicated with hyperlipemia and its effect on blood lipid level. Methods 100 patients with coronary heart disease complicated with hyperlipemia were randomly divided into the three groups according to the number table methods, the patients in group A received rosuvastatin Calcium 5mg/d, group B was given 10mg/d,group C was given 20mg/d.A treatment course was 4 weeks,and continuous treatment lasted 3 courses. The effects after treatment and serum TC,TG,LDL- C and HDL- C levels before and after treatment of the three groups were compared,and the occurrence of adverse reactions in the three groups of patients was recorded. Results The effective rate of C group in the treatment of coronary heart disease was 87.9%, the effective rate in the treatment of hyperlipidemia was 93.9%,which were significantly higher than those in group A and group B(χ2= 6.54,P<0.05); The serum TC,TG,HDL- C and HDL- C levels of three groups after treatment were significantly improved compared with before treatment,and which in C group were improved better than the other two groups(F= 5.45,P< 0.05);There was no significant adverse reactions in the three groups during treatment. Conclusion Large dose rosuvastatin Calcium has a significant therapeutic effect in treatment of coronary heart disease complicated with hyperlipemia, which can effectively regulate blood lipid levels, with no obvious adverse reaction and high security,which is worthy of clinical application. Key words: Coronary Artery Disease; Dyslipidemias; Rosuvastatin calcium