Effect of thymic peptide combined with conventional therapy on clinical efficacy for elderly patients with chronic obstructive pulmonary disease secondary pulmonary infection

Objective To compare thymic peptide injection combined with conventional therapy on clinical efficacy, quality of life and lung function for elderly patients with chronic obstructive pulmonary disease secondary pulmonary infection. Methods 110 cases of patients with chronic obstructive pulmonary disease secondary pulmonary infection were split into 2 groups.Control group was given conventional therapy alone, while observation group was given thymic peptide injection combined with conventional therapy.Clinical efficacy, quality of life, lung function and immune function of patients in two groups were compared. Results ①Clinical efficacy in observation group after treatment was significantly higher than control group after treatment (P<0.05). ② Scores of clinical symptom and quality of life in observation group after treatment were significantly lower than before treatment and control group after treatment (P<0.01). ③ Levels of FEV1 and FVC in observation group after treatment were significantly higher than before treatment and control group after treatment (P<0.05). ④Levels of CD3+ 、CD4+ /CD8+ and natural killer (NK) cells in observation group after treatment were significantly higher than before treatment and control group after treatment (P<0.05). Conclusions Thymic peptide injection combined with conventional therapy can effectively enhance clinical efficacy, improve clinical symptom and quality of life, and enhance lung function and immune function. Key words: Thymic peptide injection; Conventional therapy; Chronic obstructive pulmonary disease; Pulmonary infection; Clinical efficacy; Quality of life; Lung function