Expressions of miRNA141 and miRNA375 in serum samples from prostate cancer

To explore the diagnostic values of miRNA141 and miRNA375 for prostate cancer. The expressions of miRNA141 and miRNA375 in serum samples from 30 prostate cancer (PCA) patients, 40 benign prostatic hyperplasia patients and 50 normal controls were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The expression of miRNA141 in tissue samples from prostate cancer was 13.4±7.2 folds of that from benign prostatic hyperplasia while the expression of miRNA375 in tissue samples from prostate cancer was 28.4±10.3 folds of that from benign prostatic hyperplasia. The differential expression of miRNA141 and miRNA375 in sera of prostate cancer suggested that miRNA141 and miRNA375 might be potential tumor markers in clinical practice. Key words: Prostatic neoplasms; Laboratory techniques and procedures