Effect of Ulinastatin on Serum C-reactive Protein in Acute Pancreatitis

Objective To investigate the clinical efficacy of ulinastatin in the treatment of mild and severe acute pancreatitis and to observe its effect on the serum C-reactive protein. Methods Sixty-four cases of acute pancreatitis were randomly divided into treatment group(32 cases)and control group(32 cases),and each group was,in turn,divided into severe cases(18 cases)and mild cases(14 cases). Both treatment group and control group were given conventional therapy,and ulinastatin was added to the treatment group. The changes of serum C-reactive protein,efficiency and improvement of clinical symptoms,and the incidence of complications and mortality in the two groups were observed and compared. Results 1)There was no significant difference in the serum C-reactive protein level in the two groups before therapy,the serum C-reactive protein level was decreased in both groups after treatment but the treatment group showed an obvious decrease in it compared with the control group,with a significant difference in the serum C-reactive protein level between the two groups(P0.01). 2)The effective rate of the treatment group was 96.88%(31/32),and that of the control group was 87.50%(28/32),with a significant difference between the two groups(P0.05)). The total effective rate of severe acute pancreatitis cases of the treatment group was 92.85%,obviously higher than that of the control group(71.40%),with a significant difference(P0.05). 3)The treatment group was superior to the control group in the relief time of abdominal pain,time of serum amylase returning to normal and time of pancreatic edema improvement,with a significant difference(P0.05). 4)The incidence of hypoxemia in the treatment group was significantly lower than that of the control group,with a significant difference(P 0.05). Conclusion The conventional therapy plus ulinastatin for acute pancreatitis can improve some indicators and reduce the incidence of complications,mitigation and improvement of a variety of clinical symptoms and signs,which is economical and convenient,worthy of being popularized in clinical treatment.