The clinical efficacy of metoprolol combined with trimetazidine for cardiac failure due to coronary heart disease

Objeective To investigate the clinical efficacy of combination therapy with metoprolol and trimetazidine in the treatment of cardiac failure due to coronary heart disease (CHD).Meyhods 96 patients with cardiac failure due to CHD divided study group and control group,48 for each group.The control group received routine comprehensive treatment,while the study group received metoprolol combined with trimetazidine.The clinical efficacy and improvement in cardiac function were observed in the two groups.Results The total effectiveness rate was significantly higher in the study group than in the control group (95.83％ vs.83.33％,P＜0.05).Six months after treatment,LVEF was significantly greater while LVESD and LVEDD were markedly smaller in the study group than in the control group (P＜0.05 for all comparisons).Conclusions Combination therapy with metoprolol and trimetazidine is efficacious and has a rapid onset of action and a longer-lasting action.It can be used as an ideal therapeutic regimen for cardiac failure due to coronary heart disease. Key words: Metoprolol; Trimetazidine; Coronary heart disease; Cardiac failure