Metabolic characteristic and insulin resistance in newly diagnosed type 2 diabetes patients with nonalcoholic fatty liver disease

Objective To investigate metabolic characteristics and insulin resistance in newly diagnosed type 2 diabetes patients with nonalcoholic fatty liver disease. Methods Two hundred patients with newly diagnosed type 2 diabetes mellitus including 140 with nonalcoholic fatty liver disease （NAFLD） （NAFLD group） and 60 without NAFLD （non-NAFLD group） were recruited. Metabolic characteristic were measured and recorded, homeostasis model assessment insulin resistance （HOMA-IR） index and HOMA-C were used to assess insulin resistance. Results were compared between two groups. Results Compared with non-NAFLD group, body mass index （ BMI）, fasting blood glucose （ FBG）, alanine aminotransferase （ ALT）, gamma-glutamyl transferase （ GGT）, uric acid （UA）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, fasting insulin （FINS）, fasting C peptide （FCP）, glycated hemoglobin alc（HbAlc） , HOMA-IR, and HOMA-C were significantly higher in the NAFLD group （ P〈0. 05 ）. Logistics regression analysis showed that BMI, TG, GGT, and UA were risk factors for NAFLD （ P 〈0.05, OR = 1.82, 1.53, 1.37, and 1.09）. Conclusions Compared patients without NAFLD, newly diagnosed type 2 diabetes patients with NAFLD present more metabolic disturbance, and severely insulin resistance. Obesity and the increased level of postprandial UA, triglyceridemia, and GGT might increase the risk of NAFLD in the patients with newly diagnosed type 2 diabetes mellitus. Key words: Diabetes mellitus, type 2/complications ;  Fatty liver/complications ;  Insulin resistance ;  Body mass index ;  Bloodpressure;  Blood glucose