Effect of hyperbaric oxygen treatment on neurological function and serum hs-CRP in patients with hypertensive intracerebral hemorrhage

Objective To observe the effect of hyperbaric oxygen (HBO) treatment applied to patients with hypertensive intracerebral hemorrhage (HICH) on neurological function and serum hypersensitive C-reactive protein (hs-CRP). Methods Seventy-eight patients with HICH were randomly divided into hyperbaric oxygen (HBO) treatment group (n=42) and routine treatment (control) group (n=36). The control group was treated with conventional treatment, including craniotomy, blood pressure control, dehydration to reduce intracranial pressure and nerves nutrition. On the basis of control group, the HBO treatment group was treated with HBO therapy at the fifth day after craniotomy and lasted 20 d. The curative effects and serum hs-CRP were compared between the HBO therapy and control groups before and after treatment. Results After treatment, the curative effects were significantly higher in HBO treatment group than those in the control group (P<0.05). As compared with that before treatment, cerebral edema volume and serum hs-CRP level were obviously reduced after treatment (P<0.05) both in HBO treatment group and control group. And there were statistically significant difference in HBO treatment group and control group after treatment. Additionally, there were significant positive correlation between cerebral edema volume and serum hs-CRP levels (P<0.05). Conclusion Early treatment with hyperbaric oxygen can significantly promote the recovery of neurological function, alleviate the degree of cerebral edema and reduce the level of serum hs-CRP in patients with HICH. Key words: Hypertensive intracerebral hemorrhage; Hyperbaric oxygen; Neurological function; Hypersensitive C-reactive protein