2010•Zhonghua xingwei yixue yu naokexue zazhiRequires access

A comparative study of escitalopram angumentation with psychoanalysis in the treatment of refractory depression

Xiangjun Meng, Zhenjing Liu, Yuhuan Li, Yu-yan Jiang

Abstract

Objective To investigate the efficacy of escitalopram combined with psychoanalysis in the treatment of refractory depression. Methods A total of 63 patients were randomly divided into escitalopram group ( n = 32) and escitalopram combined with psychoanalysis group( n = 31 ). All patients were evaluated with Hamilton depression Rating Scale(HAMD). Results After treatment,the scores of HAMD in two groups were both significantly lower than those before treatment. In the 8th ( ( HAMD ( 17.35 ± 2.98 ) ), 12th ( ( HAMD (9. 26 ±3.46) )weekend of treatment, the scores of HAMD in study group were significanlly lower than those in control group(8 th:21.97 ± 3.26; 12 th: 15.28 ± 3. 18 ). There were no significant differences in side effects between study group and control group. Conclusion Escitalopram angumented with psychoanalysis takes effects better than escitalopram single and doesn't increase side effects in the treatment of refractory depression. Key words: Escitalopram; Psychoanalysis; Refractory depression

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Key concepts: Escitalopram, Hamd, Depression (economics), Refractory (planetary science), Psychology, Psychiatry, Hamilton depression scale, Internal medicine