Propylthiouracil for pregnancy complicate by hyperthyroidism in 54 women

Objective To explore the efficacy of propylthiouracil in the treatment of pregnancy complicated by hyperthyroidism.Methods 108 pregnant women with hyperthyroidism were evenly assigned to receive propylthiouracil (PTU group),or methimazole (MMI group).Levels of serum TSH,FT4 and FT3 were detected regularly.The dosage of anti-thyroid agents was adjusted according to the test results.Results Levels of serrum FT4 and FT3 were lower in PTU group than in MMI group and the rate of complications was lower in PTU group,with significant statistical differences (P＜0.05).Conclusions Propylthiouracil is the first choice in the treatment of pregnancy complicated by hyperthyroidism.It can effectively relieve symptoms of hyperthyroidism and control the development of the disease and has no adverse effects on pregnant women and fetuses.It is worth popularizing clinically. Key words: Pregnancy; Hyperthyroidism; Propylthiouracil