尹红玲, 郑晖
Abstract
目的为阐明乳腺癌组织中PTEN蛋白表达改变的意义.方法利用SP免疫组化技术检测PTEN蛋白在乳腺癌、不典型导管内上皮增生、正常乳腺组织的表达.结果乳腺癌PTEN蛋白的阳性率和阳性强度低于正常乳腺(P＜0.01)和不典型导管内上皮增生组(P＜0.05);表达强度与乳腺癌分化程度有关(P＜0.05),分化愈差,表达愈弱.不典型导管内上皮增生PTEN的表达比正常乳腺低(P＜0.05),较乳腺癌组织强(P＜0.05).结论通过检测PTEN的表达,对估计乳腺癌的预后有一定意义,可预测不典型导管内上皮增生发生癌变的可能性.
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目的为阐明乳腺癌组织中PTEN蛋白表达改变的意义.方法利用SP免疫组化技术检测PTEN蛋白在乳腺癌、不典型导管内上皮增生、正常乳腺组织的表达.结果乳腺癌PTEN蛋白的阳性率和阳性强度低于正常乳腺(P＜0.01)和不典型导管内上皮增生组(P＜0.05);表达强度与乳腺癌分化程度有关(P＜0.05),分化愈差,表达愈弱.不典型导管内上皮增生PTEN的表达比正常乳腺低(P＜0.05),较乳腺癌组织强(P＜0.05).结论通过检测PTEN的表达,对估计乳腺癌的预后有一定意义,可预测不典型导管内上皮增生发生癌变的可能性.
Key concepts: PTEN, Carcinoma, Expression (computer science), Breast carcinoma, Breast cancer, Cancer research, Pathology, Oncology