2002•中国医师杂志Requires access

The Expression of PTEN,p73 Oncoprotein and Its Significance in Gastric Cancer Tissues

唐植忠

Abstract

目的研究胃癌组织中PTEN,p73蛋白表达及其临床病理意义 .方法常规石蜡包埋切片SABC免疫组化法.结果 57例胃癌组织中PTEN阳性29例(51%)和p73阳性21例(37%),腺癌PTEN阳性率(63%)较明显高于粘液腺癌(43%)和印戒细胞癌(38%),但均无显著差异(P＞0.05);腺癌p73阳性率(26%)明显低于粘液腺癌(57%)和印戒细胞癌(44%),与粘液腺癌比较存在显著差异(P＜0.05).组织学分级Ⅰ级和淋巴结未转移病例PTEN阳性率明显高于组织学分级Ⅲ级(P＝0.032)和淋巴结转移病例(P＜0.05),组织学分级Ⅰ级和淋巴结未转移病例p73阳性率明显低于组织学分级Ⅲ级(P＝0.042)和淋巴结转移病例(P＜0.05).PTEN表达与p73表达呈密切负相关(P＜0.01).结论 PTEN和p73蛋白表达与胃癌临床病理特征和生物学行为存在密切关系,均为重要生物学标记物.

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Key concepts: PTEN, Cancer, Cancer research, Expression (computer science), Biology, Cell biology, Genetics, PI3K/AKT/mTOR pathway