Research progress of gene polymorphism of cytokines with henoch-Sch(o)nlein purpura

Henoch-Schonlein purpura (HSP) is the most common vasculitis affecting mainly children and its etiology and pathogenesis are still unclear. In recent years, some studies have shown that the polymorphisms of certain cytokine genes, e. g. , Interleukin gene, cell adhesion molecule gene, vascular endothelial growth factor gene, transforming growth factor gene, etc. , are correlated with the pathogenesis, susceptibility, progress in pathology and prognosis of HSP. Therefore, comprehensive analysis of the association between cytokine gene polymorphisms and HSP would be important may provide clues for clinical to understanding the nature of HSP on the genetic level and new research and new treatment in future. Key words: Henoch-Schonlein purpura;  Gene polymorphism;  Cytokine