黄琨, 刘厚君, 涂亚庭
Abstract
Stat 3是一种重要的核转录因子,参与细胞增殖、存活、转化、迁移等过程.Stat 3在以表皮过度增殖和/或异常分化为特征的皮肤病,如银屑病、皮肤恶性肿瘤的发病中起重要作用.通过向目的细胞内引入Stat 3反义寡核苷酸、诱饵寡核苷酸或显性负相蛋白等阻断Stat 3的功能,能抑制目的细胞的增殖,促进细胞调亡。
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Stat 3是一种重要的核转录因子,参与细胞增殖、存活、转化、迁移等过程.Stat 3在以表皮过度增殖和/或异常分化为特征的皮肤病,如银屑病、皮肤恶性肿瘤的发病中起重要作用.通过向目的细胞内引入Stat 3反义寡核苷酸、诱饵寡核苷酸或显性负相蛋白等阻断Stat 3的功能,能抑制目的细胞的增殖,促进细胞调亡。
Key concepts: Dermatology, Medicine, Biology