2004•Zhonghua gan-dan waike zazhiRequires access

Expression of STAT 1, STAT 2 and STAT 4 in primary hepatocellular carcinoma and its significance

周钧, 钟德玝, 杨竹林, 胡继雄, 邓星辉

Abstract

目的探讨STAT 1、STAT 2、STAT 4在肝癌的癌组织、癌旁组织及正常肝组织表达及其表达与原发性肝癌的关系.方法应用SABC免疫组织化学染色法检测2002年3～11月中南大学湘雅二医院肝胆胰外科手术切除原发性肝癌(PHC)标本37例和胆囊炎病人手术切除的正常肝组织17例中的STAT 1、STAT 2、STAT 4蛋白表达.结果肝癌癌组织中STAT 1、STAT 2、STAT 4蛋白表达阳性率及其评分明显低于癌旁组织和正常肝组织,均有高度显著性差异(P 0.05).STAT 1、STAT 2、STAT 4蛋白与分化和病理分型有关,与肝硬化、AFP、转移及肿瘤大小无显著差异.结论 STAT 1、STAT 2、STAT 4在肝癌癌组织表达显著降低,在癌旁组织和正常肝组织表达显著增高,STAT 1、STAT 2、STAT 4在肝癌的发生、发展中有重要相关作用。

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Key concepts: stat, Hepatocellular carcinoma, STAT4, Primary (astronomy), JAK-STAT signaling pathway, Cancer research, Medicine, Biology