Distribution of infection rate and genotype of human papilloma virus among 1 715 gynecological patients in a hospital

Objective To investigate human papilloma virus (HPV) infection rate and type distribution in gynecological patients, and to provide reference for the diagnosis and treatment of cervical cancer and the development of HPV vaccine. Methods Total of 21 HPV genotypes of 1 715 women with HPV infection screening of reproductive tract and sexual history in Baoji Traditional Chinese Medicine Hospital from November 2009 to October 2016 were detected by Rapid Biotransformation Hybridization Gene Chip Technology (Hybrimax). Results HPV58, HPV16, HPV52 and HPV33 were the most common high risk types of cervical infection, while HPV 11 and CP8304 were the main risk types of HPV. Among the 1 715 patients, 266 cases were HPV positive, the positive rate was 15.51%. There were 168 cases (9.80%) with single infection and 98 cases (5.71%) with double and multiple infection, the infection rates of HPV were higher in patients aged 31-40 years old (18.31%) and 41-50 years old (18.60%), followed by those≤30 years old, the infection rate was 13.92%. The infection rate of HPV in patients > 50 years (8.24%) was significantly lower than that in patients≤30 years old (allP< 0. 05). The high risk type of single infection were HPV58, HPV16, HPV52 and HPV33 infection in 68 cases (40.48%), 40 cases (23.81%), 22 cases (13.10%) and 10 cases (5.95%), respectively. Compared with the positive rates of HPV58, the positive rate of HPV16, HPV52 and HPV33 type were significantly different (allP< 0. 05); HPV11 and CP8304 were the main types of infection in low risk patients (16 cases, 9.52%vs. 12 cases, 7.14%), but there was no significant difference (χ2= 1.512,P= 0.186). Among the 98 cases with double or multiple infection, 62 cases (63.27%) were double infection, 28 cases (28.57%) were triple infection, 8 cases (8.16%) were quadruple infection. The main subtypes of double and multiple infection were HPV58, HPV16, HPV52 and HPV11 for 25 cases (25.51%), 20 cases (20.41%), 16 cases (16.33%) and 11 cases (11.22%), respectively. Conclusions The infection rate of high-risk HPV of gynecological patients in our hospital basically accords with the distribution of Asian population, but with some regional characteristics. Key words: Human papilloma virus; Infection; Genotype; Distribution