Clinicopathological study of P21, HER2, EGFR expression in gastric adenocarcinoma tissue

Objective To explore P21,HER2,EGFR protein expression in gastric adenocarcinoma tissue and their clinical pathological relationship.Methods Immunohistochemical technique was used in P21,HER2 and EGFR joint detection for 65 cases of gastric adenocarcinoma biopsy.The result was statistically analyzed.Results The positive expression rates of P21,HER2,EGFR were 56.9％ (37/65),43.1％ (28/65),30.8％ (20/65) respectively.Statistical analysis showed,P21,HER2,EGFR protein expression were related to gastric adenocarcinoma tissue differentiation,depth of invasion,with or without tumor thrombus,lymph node metastasis,distant metastasis and TNM stage (P ＜ 0.05 or P ＜ 0.01),not related to gender,age,tumor size,tumor location and histological type (P ＞ 0.05).P21 expression was related to HER2 and EGFR expression,and HER2 expression was related to EGFR expression (P ＜ 0.05).Conclusions P21,HER2,EGFR expression results in gastric adenocarcinoma show the existence of multi-gene expression,these genes may be involved in the occurrence and development of gastric adenocarcinoma.The joint detection is helpful in determining the biological behavior and prognosis of gastric adenocarcinoma,and provides the basis for clinical molecular targeted therapy selection. Key words: Gastric;  Adenocarcinoma;  P21;  HER2;  EGFR