2002•中华实验和临床病毒学杂志Requires access

Preliminary evidence that a hepatitis E virus(HEV)ORF2 recombinant protein protects cynomolgus macaques against challenge with wild-type HEV

毕胜利, 鲁健, 蒋琳, 黄国勇, 潘海东, 江永珍, 张明程, 沈新亮

Abstract

目的观察基因重组戊型肝炎病毒(HEV)结构蛋白对恒河猴戊型肝炎野病毒攻击的保护作用.方法用HEV重组结构蛋白免疫恒河猴,猴血清中抗-HEV升高后,与空白对照组一同用HEV野病毒攻击,采血观察野病毒攻击前后ALT和HEV抗体等的动态变化.结果野病毒攻击后第3周,空白对照组5只猴ALT均出现明显异常,而免疫接种组5只猴ALT均正常,未观察到明显的肝脏炎症表现.结论 HEV重组结构蛋白免疫恒河猴之后,可以有效地保护HEV野病毒的攻击.该HEV重组结构蛋白可作为戊型肝炎基因工程疫苗的候选蛋白.

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Key concepts: Hepatitis E virus, Virology, Recombinant DNA, Hepatitis E, Biology, Gene, Genetics, Genotype