The expression of IL-1β,IL-8 and TNT-α in induced sputum in different stages of stable chronic obstructive pulmonary disease

Objective To evaluate the expression of interleukin-1 β ( IL-1β) ; interlenkin-8 ( IL-8 ) ; tumor necrosis factor-α,(TNF-α) in induced sputum in different stages of stable chronic obstructive pulmonary disease (COPD) and heath smoking controls.Methods 90 healthy smoking controls and 100 stable COPD patients were enrolled.The levels of IL-1β,IL-8 and TNF-α in induced sputum were detected by radioimmunoassay.Results The levels of IL-1β,IL-8 and TNF-α in stable COPD patients were much higher than those in healthy smoking controls (P =0.000).There are an inverse correlation between FEV1 and levels of IL-1 β,IL-8 and TNF-α in induced sputum (r=-0.678,-0.752,-0.615,all P＜0.05).Conclusion IL-1β,IL-8 and TNF-α may play important roles in the mechanism of airway inflammation in stable COPD.The levels of IL-1 β,IL-8 and TNF-α in induced sputum may be a marke of severity of airway inflammation in stable COPD. Key words: Pulmonary disease, chronic obstructive;  Interleukin;  Tumor necrosis factor-α;  Lung funtion