The express of interleukin-1β(IL-1β),interlenkin8(IL-8) and tumor necrosis factor-α(TNF-α) at different stage of stable chronic obstructive pulmonary disease(COPD)

Objective To evaluate the express of Interleukin-1β(IL-1β),Interlenkin-8(IL-8) and tumor necrosis factor-α(TNF-α) in induced sputum and serum in different stages of stable chronic obstructive pulmonary disease(COPD).Methods 90 health smoking controls and 100 stable chronic obstructive pulmonary disease(COPD) patients were enrolled.The levels of IL-1β,IL-8 and TNF-α in induced sputum and blood serum were detected by radioimmunoassay.Results The levels of IL-1β,IL-8 and TNF-α in stable chronic obstructive pulmonary disease(COPD) patients were much higher than that in health smoking controls.There were an inverse correlation between FEV1 and level of IL-1β,IL-8 and TNF-α in induced sputum and blood serum.Conclusion IL-1β,IL-8 and TNF-α may play important roles in the mechanism of airway inflammation in stable chronic obstructive pulmonary disease(COPD).The level of IL-1β,IL-8 and TNF-α in induced sputum and serum may be a suggestion of the order of severity of airway inflammation in stable chronic obstructive pulmonary disease(COPD).