The effect of traditional Chinese medicine on the renal function and quality of life in early diabetic nephropathy patients

Objective To investigate the effect of traditional Chinese medicine on the renal function and quality of life in patients with early diabetic nephropathy (DN). Methods 78 diagnosed as DN and TCM syndrome type belonged to cases of yin deficiency of liver and kidney were included in the study, they were randomly divided into the control group(40 cases) and observation group (38 cases). The two groups underwent conventional treatment of western medicine, the observation group received traditional Chinese medicine.The 24h urine protein counts, blood glucose (FBG, 2hPG), lipid column (TC, TG, LDL-C, HDL-C), UAER, ACR, SCR, bun and quality of life of SF-36, adverse reaction were observed. Results The blood glucose, blood pressure, UAER, ACR, SCR, BUN, SF-36 score, urinary protein count of the two groups were improved than before treatment.6 months after treatment, the 24h urine protein of observation group was (1.02±0.42)g, which was significantly lower than the control group, the difference was statistically significant (t=2.702, P<0.05). After treatment, UAER, ACR, SCr, BUN of the observation group were (82.09±10.74)mg/24h, (84.92±9.33)mg/g, (108.43±38.35)mmol/L, (6.17±2.65)mmol/L, which were better than the control group, the differences were statistically significant (t=8.960, P<0.01; t=15.528, P<0.01; t=11.987, P<0.01; t=10.566, P<0.01). No adverse reaction was observed. Conclusion The combination of Chinese and western medicine in the treatment of early DN has good efficacy and better than the use of western medicine alone, it can improve renal function and is safe and reliable. Key words: Drug therapy, combination; Diabetic nephropathy; Quality of life