Analysis of 4-year trend of the prevalence of hyperuricemia and related metabolic factors in urbanized community population in Hangzhou

Objective To understand the trends of the prevalence of hyperuricemia of urbanized community residents Sijiqing Streets in Jianggan district in Hangzhou in the past 4 years, and analyze the correlation between hyperuricemia and metabolic factors, which provide scientific endence for prevention and treatment of hyperuricemia in communities. Methods 1 670 cases equal to or greater than 20 years old were randomly selected to analyze the trends of the prevalence of hyperuricemia in the past 4 consecutive years, which from urbanized community physical examination in 2010 to 2013(male 749 cases, female 921cases). Comparative analysis of age, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, glycosylated hemoglobin (HbA1C), TG, TC, LDL-C, and HDL-C levels between hyperuricemia group(male 264 cases, female 181 cases) and non hyperuricemia group(male 485 cases, female 740 cases) on 2013, and analyze the related metabolic factors to hyperuricemia by using non conditional logistic regression analysis. Results ①From 2010 to 2013, male hyperuricemia prevalence rates were 27.9% (209/749, standardized rates were 27.4%)、29.1%(218/749, standardized rates were 27.9%), 33.2%(249/749, standardized rates were 31.8%)and 35.2%(264/749, standardized rates were 32.9%). The prevalence rates of female were 12.6%(116/921, standardized rates were 11.7%), 13.5%(124/921, standardized rates were 11.9%), 18.0%(166/921, standardized rates were 15.7%) and 19.7(181/921, standardized rates were 17.2%), showed a increased tends year by year (the χ2 of tends of male and female were 11.907 and 22.759, respectively, all P 0.05). ③The non conditional Logistic regression analysis showed that, independent risk factor for male hyperuricemia were overweight (OR: 2.151, 95%CI: 1.439-3.215) or obese (OR: 2.882, 95%CI: 1.541-5.389), hypertension (OR: 1.564, 95%CI: 1.100-2.224), dyslipidemia (OR: 1.678, 95%CI: 1.165-2.417) and abdominal obesity (OR: 1.708, 95%CI: 1.146-2.547), independent risk factors for hyperuricemia in women were overweight (OR: 2.067, 95%CI: 1.290-3.313) or obese (OR: 2.843, 95%CI: 1.523-5.309), hypertension (OR: 1.530, 95%CI: 1.042-2.248), dyslipidemia (OR: 1.784, 95%CI: 1.191-2.672) and hyperglycemia (OR: 1.768, 95%CI: 1.221-2.561). Conclusions The community people have a higher prevalence of hyperuricemia, which showed a increased trend, especially in the middle and old age year by year; overweight or obesity, abdominal obesity, hypertension and dyslipidaemia influence male prevalence rate of hyperuricemia, overweight or obesity, hypertension, hyperglycemia and dyslipidemia influence female prevalence rate of hyperuricemia, we should strengthen the comprehensive prevention and treatment of hyperuricemia in this community. Key words: Hyperuricemia; Prevalence; Risk factors