Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors

Objective To investigate the prevalence of hyperuricemia and its risk factors in the adult population aged 35-70 years from 9 provinces.Methods 15 706 residents were recruited from the cross-sectional survey to determine the prevalence of hyperuricemia.Logistic regression model was used to investigate the association between uric acid levels and the various cardiovascular risk factors.Results The prevalence of hyperuricemia was 12.08% and was higher for men(14.59%)than women(10.21%).The increasing prevalence of hyperuricemia with age can be seen in female population(P0.05),but not in the male population(P0.05).The main concomitant disease of hyperuricemia were hyperlipemia(80.4%),then overweight and obesity(74.61%),elevated blood pressure(58.32%),abdomen obesity(45.47%),diabetes(11.80%).In a multivariate logistic regression model,age(OR=1.01,95% CI:1.01-1.02),male gender(OR=1.36,95% CI:1.21-1.53),obesity(OR=1.69,95% CI:1.52-1.88),hypertriglyceridemia(OR=4.28,95%CI:3.84-4.76),hypercholesteremia(OR=1.19,95% CI:1.06-1.33),elevated blood pressure(OR=1.17,95% CI:1.05-1.30),and drinking(OR=1.36,95% CI:1.19-1.56)were associated with increased risk of hyperuricemia.Conclusions Hypertriglycedemia,hypercholesteremia,male gender,elevated blood pressure,obesity and drinking are associated with increased risk of hyperuricemia.With the growing incidence of obesity and metabolic syndrome and the positive relationship between hyperuricemia and cardiovascular diseases,we need pay more attention to the control of hyperuricemia.