Clinical observation of penehyclidine hydrochloride compared with atropine and scopolamine as the preanesthetic medication for the infant

Objective To compare the effects of penehyclidine hydrochlofide,atropine and scopolamine as the preanesthetic medication for the infant.Methods Ninety infants patients who would undergo general anesthesia with tracheal intubation were divided randomly into three groups as follow:penehyclidine hydrochloride group(PHEgroup),atropine group(ATR group)and scopolamine group(SCO group),30 patients in each group.Penehyclidine hydrochloride(0.02mg/kg),atropine(0.01 mg/kg)or scopolamine(0.006 mg/kg)was injected intramuscularly respec-tively 30 minutes before operations.The changes of heart rate,temperature,blood pressure and the secretion of respiratory tract were observed and recorded before medication,15 minutes and 30 minutes after medication,after trachea cannula and after extubate.Results There were little difference among the three groups in gender,age,body weight and operation time.There were no significant changes in heart rate,temperature and blood pressure in group PHE after medication (P>0.05).Compared to PHE group,heart rate and temperature in ATR group and SCO groupincreased significantly(P 0.05).The secretion of respiratory tract was decreased significantly in PHE group compared to those in ATR group and SCO group after operation(P<0.05).Catmlusion Penehyclidine hydrochloride has no significant effect on heart rate and temperature and blood pressure,and it's effect of inhibiting glandular secretion is longer than atropine and scopolamine.Therefore,Penehyclidinehydrochloride as the preanesthetic medication is safety for the infant. Key words: Penehyclidine ydrochloride; Atropine; Scopolamine; Preanesthetic medication; Infant