A Clinical Study of Penehyclidine Hydrochloride as Premedication of General Anesthesia in Neonates's Surgery

Objective To investigate and compare the clinical effect of Penehyclidine Hydrochloride used as premedication of general anesthesia to Atropine on neonates's surgery.Methods In a randomized study,30 neonates patients were divided into two groups:group P (Penehyclidine Hydrochloride group,n=15) and group A (Atropine group,n=15).Group P was injected muscularly with 0.02mg/kg Penehyclidine Hydrochloride 30 minutes before general anesthesia,while group A were administered with 0.02mg/kg Atropine respectively.The heart rate(HR),blood pressure(BP) and pulse oxygen saturation(SPO2) were recorded before medication(T0) and 15min(T1),30 min(T2) after medication.The secretion of respiratory tract,facial flushing at T0,T1,T2 and T3(tracheal catheter extracting) were evaluated.Results There was no significant difference between the sex,age,weight and surgery time of the neonates patients in two groups(P0.05);and no obvious change appeared in the heart rate of the patients in group P(P0.05).While the heart rate of the patients in the group A significantly increase comparing to the basal value 15 and 30 minutes after medication (P0.05).Moreover,secretion of respiratory tract was prominently decreased in group P at T3 comparing to group A (P0.05).Conclusion Penehyclidine Hydrochloride has significant effects of inhibiting secretion of salivary glands,maintaining cardiovascular stability,and is a proper premedication of surgery in neonates patients undergoing general anesthesia.