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2019•Chin J Reprod ContracepRequires access

Gonadotropin-releasing hormone antagonist protocol improves embryo quality and in vitro fertilization outcomes in poor ovarian response patients with repeated in vitro fertilization failure: a self-controlled study

Wei Wang, Ting Yang, Jiajing He, Xiaoling Ma, Lihui Zhao, Junping Hu, Shilong Xue

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Abstract

Objective To discuss the effect of gonadotropin-releasing hormone antagonist (GnRH-A) protocol on the improvement of embryo quality and pregnancy outcome after the pregnancy failure of gonadotropin-releasing hormone agonist (GnRH-a) protocol performed for the poor ovarian response (POR) patients who suffered repeated in vitro fertilization (IVF) failure accompanied by poor embryo quality. Methods A self-controlled study was carried out retrospectively to analyze 53 POR patients who switch to GnRH-A protocol after the pregnancy failure performed by the GnRH-a protocol in the Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University from February 2017 to February 2018. The duration of gonadotropin (Gn) used, total dosage of Gn used, the levels of estradiol, luteinizing hormone (LH) and progesterone on the day of hCG injection, endometrial thickness on the day of hCG injection, No. of oocytes retrieved, fertilization rate, cleavage rate, No. of embryos obtained for embryo transfer, rate of high-quality embryos, No. of embryos transferred, endometrial thickness on the day of embryo transfer, implantation rate, cancelling rate between GnRH-A and GnRH-a groups were compared, and the clinical pregnancy rate of GnRH-A group was also calculated. Results The duration of Gn used [(11.3±3.4) d], total dosage of Gn used [(2 827.6±427.4) IU], LH level on the day of hCG injection [(1.24±0.76) IU/L], cancelling rate (5.66%) of GnRH-A group were significantly lower than those of GnRH-a group [(13.7±3.7) d, P 0.05). And the clinical pregnancy rate of GnRH-A group was 32.00%. Conclusion The GnRH-A protocol may help to improve embryo quality and IVF outcomes for POR patients after the pregnancy failure performed by the GnRH-a protocol. Key words: Gonadotropin-releasing hormone antagonist; Poor ovarian response; Embryo quality; Fertilization in vitro; Self-controlled study

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What this paper is about

Objective To discuss the effect of gonadotropin-releasing hormone antagonist (GnRH-A) protocol on the improvement of embryo quality and pregnancy outcome after the pregnancy failure of gonadotropin-releasing hormone agonist (GnRH-a) protocol performed for the poor ovarian response (POR) patients who suffered repeated in vitro fertilization (IVF) failure accompanied by poor embryo quality. Methods A self-controlled study was carried out retrospectively to analyze 53 POR patients who switch to GnRH-A protocol after the pregnancy failure performed by the GnRH-a protocol in the Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University from February 2017 to February 2018. The duration of gonadotropin (Gn) used, total dosage of Gn used, the levels of estradiol, luteinizing hormone (LH) and progesterone on the day of hCG injection, endometrial thickness on the day of hCG injection, No. of oocytes retrieved, fertilization rate, cleavage rate, No. of embryos obtained for embryo transfer, rate of high-quality embryos, No. of embryos transferred, endometrial thickness on the day of embryo transfer, implantation rate, cancelling rate between GnRH-A and GnRH-a groups were compared, and the clinical pregnancy rate of GnRH-A group was also calculated. Results The duration of Gn used [(11.3±3.4) d], total dosage of Gn used [(2 827.6±427.4) IU], LH level on the day of hCG injection [(1.24±0.76) IU/L], cancelling rate (5.66%) of GnRH-A group were significantly lower than those of GnRH-a group [(13.7±3.7) d, P 0.05). And the clinical pregnancy rate of GnRH-A group was 32.00%. Conclusion The GnRH-A protocol may help to improve embryo quality and IVF outcomes for POR patients after the pregnancy failure performed by the GnRH-a protocol. Key words: Gonadotropin-releasing hormone antagonist; Poor ovarian response; Embryo quality; Fertilization in vitro; Self-controlled study

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Available abstract

Objective To discuss the effect of gonadotropin-releasing hormone antagonist (GnRH-A) protocol on the improvement of embryo quality and pregnancy outcome after the pregnancy failure of gonadotropin-releasing hormone agonist (GnRH-a) protocol performed for the poor ovarian response (POR) patients who suffered repeated in vitro fertilization (IVF) failure accompanied by poor embryo quality. Methods A self-controlled study was carried out retrospectively to analyze 53 POR patients who switch to GnRH-A protocol after the pregnancy failure performed by the GnRH-a protocol in the Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University from February 2017 to February 2018. The duration of gonadotropin (Gn) used, total dosage of Gn used, the levels of estradiol, luteinizing hormone (LH) and progesterone on the day of hCG injection, endometrial thickness on the day of hCG injection, No. of oocytes retrieved, fertilization rate, cleavage rate, No. of embryos obtained for embryo transfer, rate of high-quality embryos, No. of embryos transferred, endometrial thickness on the day of embryo transfer, implantation rate, cancelling rate between GnRH-A and GnRH-a groups were compared, and the clinical pregnancy rate of GnRH-A group was also calculated. Results The duration of Gn used [(11.3±3.4) d], total dosage of Gn used [(2 827.6±427.4) IU], LH level on the day of hCG injection [(1.24±0.76) IU/L], cancelling rate (5.66%) of GnRH-A group were significantly lower than those of GnRH-a group [(13.7±3.7) d, P 0.05). And the clinical pregnancy rate of GnRH-A group was 32.00%. Conclusion The GnRH-A protocol may help to improve embryo quality and IVF outcomes for POR patients after the pregnancy failure performed by the GnRH-a protocol. Key words: Gonadotropin-releasing hormone antagonist; Poor ovarian response; Embryo quality; Fertilization in vitro; Self-controlled study

Key concepts: In vitro fertilisation, Embryo transfer, Pregnancy rate, Gonadotropin, Pregnancy, Luteinizing hormone, Embryo quality, Medicine

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Gonadotropin-releasing hormone antagonist protocol improves embryo quality and in vitro fertilization outcomes in poor ovarian response patients with repeated in vitro fertilization failure: a self-controlled study — Research Paper | ScholarLens