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2011•Chinese Journal of Clinical Obstetrics and GynecologyRequires access

Comparison of GnRH-agonist long protocol with GnRH-antagonist protocol in women with advanced reproductive-age undergoing IVF-ET

Quan Son

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Abstract

Objective To explore a better effect of controlled ovarian stimulation protocol on infertile women with advanced reproductive age by comparing gonadotropin-eleasing hormone agonist (GnRH-a)long protocol with gonadotropin-releasing hormone antagonist (GnRH-ant)protocol during in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis has been conducted on 156 infertile women (35～40 years old) who underwent IVF-ET in the Centre of Nanfang Hospital,Southern Medical University from January 2007 to June 2010.Results There was no significant difference between total dosage of gonodotropin (Gn)and progesterone (P)levels on day of hCG administration. However,there were significant differences among estrogen (E2)levels,thickness of endometrium on day of hCG administration and the length of gonadotropin application between GnRH-a group and GnRH-ant group(P0.01). Meanwhile,our results showed that LH levels on day of hCG administration in GnRH-ant group were higher than that in GnRH-a group(P0.05). The amount of retrived oocytes,matured oocytes,fertilized oocytes and normally fertilized oocytes (2PN)in GnRH-a group were higher than that in GnRH-ant group(P0.001). The clinical pregnancy rate and the implantation rate of GnRH-a group were higher than those of GnRH-ant group(P0.001).Conclusions The application of GnRH-a long protocol may improve the clinical outcomes of IVF-ET according to our study. The GnRH-a long protocol may be benificial for women with advanced age undergoing IVF-ET.

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What this paper is about

Objective To explore a better effect of controlled ovarian stimulation protocol on infertile women with advanced reproductive age by comparing gonadotropin-eleasing hormone agonist (GnRH-a)long protocol with gonadotropin-releasing hormone antagonist (GnRH-ant)protocol during in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis has been conducted on 156 infertile women (35～40 years old) who underwent IVF-ET in the Centre of Nanfang Hospital,Southern Medical University from January 2007 to June 2010.Results There was no significant difference between total dosage of gonodotropin (Gn)and progesterone (P)levels on day of hCG administration. However,there were significant differences among estrogen (E2)levels,thickness of endometrium on day of hCG administration and the length of gonadotropin application between GnRH-a group and GnRH-ant group(P0.01). Meanwhile,our results showed that LH levels on day of hCG administration in GnRH-ant group were higher than that in GnRH-a group(P0.05). The amount of retrived oocytes,matured oocytes,fertilized oocytes and normally fertilized oocytes (2PN)in GnRH-a group were higher than that in GnRH-ant group(P0.001). The clinical pregnancy rate and the implantation rate of GnRH-a group were higher than those of GnRH-ant group(P0.001).Conclusions The application of GnRH-a long protocol may improve the clinical outcomes of IVF-ET according to our study. The GnRH-a long protocol may be benificial for women with advanced age undergoing IVF-ET.

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Available abstract

Objective To explore a better effect of controlled ovarian stimulation protocol on infertile women with advanced reproductive age by comparing gonadotropin-eleasing hormone agonist (GnRH-a)long protocol with gonadotropin-releasing hormone antagonist (GnRH-ant)protocol during in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis has been conducted on 156 infertile women (35～40 years old) who underwent IVF-ET in the Centre of Nanfang Hospital,Southern Medical University from January 2007 to June 2010.Results There was no significant difference between total dosage of gonodotropin (Gn)and progesterone (P)levels on day of hCG administration. However,there were significant differences among estrogen (E2)levels,thickness of endometrium on day of hCG administration and the length of gonadotropin application between GnRH-a group and GnRH-ant group(P0.01). Meanwhile,our results showed that LH levels on day of hCG administration in GnRH-ant group were higher than that in GnRH-a group(P0.05). The amount of retrived oocytes,matured oocytes,fertilized oocytes and normally fertilized oocytes (2PN)in GnRH-a group were higher than that in GnRH-ant group(P0.001). The clinical pregnancy rate and the implantation rate of GnRH-a group were higher than those of GnRH-ant group(P0.001).Conclusions The application of GnRH-a long protocol may improve the clinical outcomes of IVF-ET according to our study. The GnRH-a long protocol may be benificial for women with advanced age undergoing IVF-ET.

Key concepts: Medicine, Gonadotropin-releasing hormone, In vitro fertilisation, Agonist, Andrology, Gynecology, Embryo transfer, Hormone antagonist

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Comparison of GnRH-agonist long protocol with GnRH-antagonist protocol in women with advanced reproductive-age undergoing IVF-ET — Research Paper | ScholarLens