Diagnostic value of P-selectin and platelet count on patients with severe infection

Objective To investigate the P-selectin and platelet count in the evaluation,prediction of severity and prognosis of patients with severe infection and its clinical significance.Methods Eighty patients in RICU of the first affiliated hospital of Zhengzhou university for severe respiratory infections from September 2011 to September 2012 were divided into SIRS group(group A) and non-SIRS group of 40 patients (group B) according to the criteria for the diagnosis of system inflammatory response syndrome (SIRS) in the ACCM/SCCM1991 Chicago conference.Forty cases of healthy persons were chosen as control group (group C).The test results of P-selectin and platelet count were compared among the three groups,then the test result of P-selectin and platelet count between survival group and the death group according to the prognosis of group A were compared.Results The plasma level of P-selectin of group A was higher than that of group B and group C,but the platelet count was lower,the difference was significant.The level of P-selectin of the death group was significantly higher than that of the survival group,but the platelet count was significantly lower.Conclusions The test result of P-selectin and platelet count can be used as important indicators to evaluate the prognosis and severity of the patients with severe infection. Key words: Severe infection ;  Systemic inflammatory response syrdrome ;  P-selectin ;  Platelet ; Prognosis