Effect of Yixintai granule on myocardial remodeling in rabbits with chronic heart failure

Objective To explore the effect of Yixintai granule on myocardial remodeling in rabbits with chronic heart failure (CHF). Methods The rabbit model of CHF with adriamycin was established. These successful CHF models of rabbits were divided into model group, high, middle, and low dose of Yixintai groups, losartan potassium group, and normal control group. Echocardiographic indexes and myocardial remodeling indexes were measured after 4 weeks of medication. Results Compared to the model group, the left ventricular posterior wall (LVPW), left ventricular internal diameter at end-systole (LVIDs), left ventricular internal diameter at end-diastole (LVIDd), cardiac index (CI), and left ventricular mass index (LVWI) of the treatment groups were decreased (P<0.05 or P<0.01), and the interventricular septum (IVS) of the middle and high Yixintai groups was decreased significantly (P<0.01). Compared to the low dose of Yixintai group, the IVS, LVPW, CI, and LVWI of the middle and high Yixintai groups were decreased (P<0.05 or P<0.01), and the LVIDs and LVIDd of the high Yixintai group were decreased (P<0.05). Conclusions Yixintai granule can improve myocardial remodeling in rabbits with CHF. Meanwhile, the curative effect of medial and high groups of Yixintai is better than the low dose group. Key words: Heart failure/PA/ZD; Ventricular remodeling/DE; CARDIOVASCULAR AGENTS(TCD)/AD