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The observation of therapeutic effect of mifepristone on dysfunctional uterine bleeding during peri-menopausal period

赵立霞, 魏云霞

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Abstract

目的观察米非司酮治疗围绝经期功能性子宫出血的临床效果.方法将44例确诊为围绝经期功能性子宫出血患者,口服米非司酮10mg,每日1次,连服3个月,观察子宫大小、内膜厚度及月经恢复情况.结果子宫内膜变薄,用药前为(5.8±0.2)mm,用药后为(2.7±0.3)mm,前后比较有显著性差异(P<0.05);子宫大小用药前后无明显差异(P>0.05).所有患者用药期间均闭经,其中有9例直接进入绝经,其余停药后25~68天,平均40.4天恢复月经,15例月经稀发、量少.结论米非司酮可抑制子宫内膜生长,治疗围绝经期功能性子宫出血效果可靠.

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目的观察米非司酮治疗围绝经期功能性子宫出血的临床效果.方法将44例确诊为围绝经期功能性子宫出血患者,口服米非司酮10mg,每日1次,连服3个月,观察子宫大小、内膜厚度及月经恢复情况.结果子宫内膜变薄,用药前为(5.8±0.2)mm,用药后为(2.7±0.3)mm,前后比较有显著性差异(P<0.05);子宫大小用药前后无明显差异(P>0.05).所有患者用药期间均闭经,其中有9例直接进入绝经,其余停药后25~68天,平均40.4天恢复月经,15例月经稀发、量少.结论米非司酮可抑制子宫内膜生长,治疗围绝经期功能性子宫出血效果可靠.

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Available abstract

目的观察米非司酮治疗围绝经期功能性子宫出血的临床效果.方法将44例确诊为围绝经期功能性子宫出血患者,口服米非司酮10mg,每日1次,连服3个月,观察子宫大小、内膜厚度及月经恢复情况.结果子宫内膜变薄,用药前为(5.8±0.2)mm,用药后为(2.7±0.3)mm,前后比较有显著性差异(P<0.05);子宫大小用药前后无明显差异(P>0.05).所有患者用药期间均闭经,其中有9例直接进入绝经,其余停药后25~68天,平均40.4天恢复月经,15例月经稀发、量少.结论米非司酮可抑制子宫内膜生长,治疗围绝经期功能性子宫出血效果可靠.

Key concepts: Mifepristone, Peri, Dysfunctional uterine bleeding, Medicine, Obstetrics, Gynecology, Internal medicine, Pregnancy

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