Clinical application of tacrolimus in 30 eases of cadaver renal transplantation

Objectives To summarize the experiences of clinical use of tacrolimus as an alternative to cyclosporin in cadaver renal transplantation.Methods Blood concentrations and side effects of tacrolimus were observed for 3 months in 30 cases of cadaver renal transplantation.Results Renal functions were retumed to normal in the 30 cases after operation.No rejection occurred during the application of tacrolimus.The blood concentrations of tacrolimus were 5～7μg/L in 3 cases,8～15μg/L in 25 cases and 32-38μg/L in 2 cases,respectively.The main side effects of tacrolimus including marrow depression and hyperglycemia.Conclusions Tacrolimus is a highly effective immunosuppressive agent.When blood trough concentrations of tacrolimus are relatively low in the patients with normal renal function,there is no need to increase the dosage of tacmlinms.Tacrolimus is less harmful to liver and may be the best choice as an immunosuppressive therapy for patients with chronic hepatitis or abnormal liver function. Key words: Kidney transplantation; Immunosuppressive agents; Treatment outcome; Drug toxicity