2000•中华器官移植杂志Requires access
Prevention and trealment of hepatitis B virus reinfection following liver transplantation
郑树森, Wu Jian, 梁廷波, 王伟林, 黄东胜, 马伟杭
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Abstract
Objective To prevent and early diagnose hepatitis B virus(HBV) reinfection and recurrent hepatitis B following liver transplantation.and to discuss the further treatment of recurrent hepatitis B.Methods Patients undergoing liver transplantation received lamivudine to prevent HBV reinfection.Virological and biochemical data,serum HBV-DNA,and immunohistological staining for HBsAg and HBcAg in biopsy liver tissue were tested in due time.Results Of 4 cases diagnosed as having HBV reinfection,two presented hepatitis B recurrence after liver transplantation:One developed to chronic severe hepatitis B after great efforts of treatment and one improved after a series of treatment.Conclusions HBV reinfection or recurrent hepatitis B following liver transplantation occurred mostly about 6 to 12 months after operation.It should be considered hepatitis B recurrence when liver biochemistrical data became poor during this period.The treatment for recurrent hepatitis B after liver transplantation included increasing dosage of lamivudine.application of famciclovir,and other liver protective measures.
Key words:
Liver transplantation; Hepatitis B virus; Recurrence