The effect of Huolisu oral liquid combined with mirtazapine tablets on the expression of NE,5-HT in the patients with depression

Objective To observe the effect of Huolisu oral liquid combined with mirtazapine tablets on the expressions of NE and 5-HT in the patients with depression,and explore the therapeutic efficiency. Methods 75 patients with depression were randomly divided into a study group with 43 cases,which were treated with Huolisu oral liquid and mirtazapine tablets and a control group with 32 cases,which were only treated with mirtazapine tablets The Hamilton depression scale（HAMD）score, serum NE,and 5-HT were detected in the patients before the treatment and 4 and 8 weeks after the treatment separately. Results Before treatment,there were no statistical significance in HAMD score,serum depression NE and 5-HT（t=0.501, 0.520, 0.611,P〉0.05）. After treated for 4 and 8 weeks, compare with the control group, HAMD score was decreased（t=1.829、2.263, P〈0.05）, serum 5-HT was increased（t=2.119, 2.870, P〈0.05）,and NE was increased in the study group（t=2.264, 2.705,P〈0.05）. Conclusion Huolisu oral liquid combined with mirtazapine tablets can significantly decrease HAMD score,and increase serum NE and 5-HT level. The treatment can improve the depression symptoms in the patients with depression obviously. Key words: Huolisu oral liquid; Mirtazapine; Depression; NE; 5-HT