Clinical observation of dexmedetomidine to prevent the cardiovascular responses to double-lumen endotracheal intubation during general anesthesia

Objective To observe the effect of dexmedetomidine on preventing the cardiovascular response to double lumen endotracheal tube intubation.Methods Eighty ASA Ⅰ-Ⅱ patients scheduled to have double-lumen endotracheal intubation under general anesthesia were randomly divided into two groups,dexmedetomidine group and control group,40 patients in each group.Dexmedetomidine was intravenous infused dating 0.5 μg/kg,5 min infusion finished before induction in dexmedetomidine group.The control group was in the same way pumpl infused with normal saline.Induced drug in both groups were sufentanil 0.3 μg/kg,rocuronium 1 mg/kg,propofol 2 mg/kg.Systolic blood pressure(SBP),diastolic blood pressure (DBP),heart rate (HR) at the time before and after administred drugs,before and during intubation,and 1 min,3 min,5 min after intubation were compared between the two groups.Results The values of BP and HR in dexmedetomidine group after intubation for 1 min were increased to varying degrees,the dexmedetomidine group increased significantly less than the control group (P ＜ 0.01).Under no deepen anesthesia,the values of BP and HR in dexmedetomidine group after intubation for 3 min and 5 min decreased compared with after intubation 1 min,and similar to values before intubation.There was no significant changes in the control group after intubation for 1 minute (P ＞ 0.05),but significantly higher than that of dexmedetomidine group (P ＜ 0.01).There were 2 patients in dexmedetomidine group occurred significant bradycardia and were corrected by atropine 0.5 mg.Conclusions Dexmedetomidine can significantly reduce the cardiovascular responses to double-lumen endotracheal tube,and help to maintain hemodynamic stability. Key words: Dexmedetomidine; Double-lumen endotracheal tube; Cardiovascular response to intubation