Effects of Dexmedetomidine in Preventing Adverse Reactions from Tracheal Intubation under General Anesthesia

Objective To investigate the effects of dexmedetomidine in preventing adverse reactions induced by endotracheal intubation.Methods A total of 48 patients underwent endotracheal intubation were randomly divided into the control group and the dexmedetomidine(DXM) group(24 each).Systolic blood pressure(SBP),diastolic blood pressure(DBP) and heart rate(HR) were monitored and recorded before induction,before intubation,at intubation,1 min,2 min and 5 min after intubation.Results In the control group,SBP,DBP decreased both before induction and before intubation(P0.05).SBP,DBP and HR increased at intubation,1 min and 2 min after intubation in comparison with before induction(P0.05).In the DXM group,SBP,DBP and HR decreased both before induction and before intubation(P0.01);SBP,DBP and HR at intubation and 1 min,2 min after intubation were significantly different between the two groups(P0.05);HR of the two groups were significantly different 5 min after intubation(P0.05).Conclusion Dexmedetomidine inhibits endotracheal intubation adverse reactions while reduces the cardiovascular response effectively.