Clinical pathological features of IgA nephropathy with nephrotic syndrome and the risk factors for impairment of renal pathology

Objective To investigate the clinical pathological features of IgA nephropathy with nephrotic syndrome and risk factors for impairment of renal pathology. Methods 121 cases of IgA nephropathy with nephrotic syndrome were selected, all patients had been diagnosed with biopsy.The clinical pathological features wer analyzed, they were divided into two groups according to different kidney disease.The minor pathological changes which Lee's classification grade Ⅰ and grade Ⅱ patients belong to group A, with a total of 36 cases, while Lee's pathology heavier grade for grade Ⅲ, Ⅳ and Ⅴ grade level in patients belonging to group B, with a total of 85 cases.Clinical characteristics and clinical laboratory indicators of two groups were compared, and risk factors for renal pathological damage were analyzed in multivariate analysis. Results The average duration of group B was significantly longer than the average duration of group A, the difference was statistically significant (t=12.74, P 5.0×107/L were dangerous aggravating factors. Conclusion Hemoglobin protective factors for IgA nephropathy with nephrotic syndrome, the mean arterial pressure, 24h urinary protein excretion and urine red blood cells are their risk aggravating factors, they can make a more accurate judgment of the patient's condition. Key words: Nephrotic syndrome; IgA nephropathy; Pathology, clinical; Factor analysis, statistics