Curative effect of clopidogrel combined with alprostadil on acute cerebral infarction and its effect on hemorheology and inflammatory factor levels

Objective To investigate the curative effect of clopidogrel combined with alprostadil on acute cerebral infarction and its effect on hemorheology and inflammatory factor levels. Methods A total of 82 ACI patients were randomly divided into observation group and control group, with 41 cases in each group. The control group was given conventional treatment, and the observation group were treated with clopidogrel combined with alprostadil. The total effective rates and adverse reaction rates of the two groups after 2 weeks were statistically analyzed. And before treatment and 2 weeks after treatment, PAR, platelet aggregation rate indexes [low blood viscosity blood flow(WBLSV), plasma viscosity(PV), whole blood viscosity(HBV)], inflammatory cytokine [interleukin-6(IL-6), C- reactive protein(CRP)] were compared. Results After 2 weeks of treatment, the total effective rate of the observation group was 90.24%(37/41), and which was higher than that of the control group [68.29%(28/41)], the difference was significant(P<0.05). The levels of PAR, WBLSV, HBV, PV in the observation group after 2 weeks of treatment were lower than those of the control group, the differences were significant (P<0.05). Compared with before treatment, 2 weeks after treatment, the levels of IL-6, CRP were reduced, and the levels of the observation group were lower than those of the control group, the differences were significant (P<0.05). The blood routine and liver function examination showed no abnormality. There was one case of medicine rash in the observation group. Conclusions Clopidogrel combined with alprostadil can improve the hemorheology of patients with acute cerebral infarction, and it can alleviate the body inflammatory response and improve efficacy. Also it has high security. Key words: Acute cerebral infarction; Alprostadil; Inflammatory factor; Clopidogrel; Hemorheology