Gonadotropin-releasing hormone analog in combination with growth hormone for girls with post-menarche idiopathic central precocious puberty

Objectives To observe the clinical effect of gonadotropin-releasing hormone analog in combination with growth hormone in the treatment of girls with post-menarche idiopathic central precocious puberty and provide some references for the clinical treatment of the disease.Methods 32 girls with postmenarche idiopathic central precocious puberty were selected from our hospital.They were treated with gonadotropin-releasing hormone analog and growth hormone for 6 months.The bone age,breast tanner staging,height,standard deviation scores of height,predicted adult height changes,growth rate,ovarian and uterine volume were observed before and after the treatment.At the same time,luteinizing hormone and follicle stimulating hormone were compared.Results The actual age,bone age,the ratio of actual age to bone age,Tanner stage and HtSDScA showed no significant differences before and after the treatment (P ＞ 0.05).After the treatment,the height,predicted adult height,and growth rate were significantly higher than that before the treatment,but HtSDSBA was significantly lower than that before the treatment (P ＜ 0.05).After the treatment,the uterine volume was (1.37 ± 0.47) cm3 and the ovarian volume was (1.12 ± 0.46) cm3,which were significantly lower than those before the treatment (P ＜ 0.05).After the treatment,the highest concentration of luteinizing hormone was (1.57 ± 0.67) U/L and the highest concentration of follicle stimulating hormone was (3.52 ± 0.81) mU/ml,which were significantly lower than those before the treatment (P ＜ 0.05).Conclusions Gonadotropin-releasing hormone analog in combination with growth hormone in the treatment of girls with post-menarche idiopathic central precocious puberty can improve the patient's predicted adult height and worth being clinically generalized. Key words: Gonadotropin-releasing hormone analog;  Growth hormone;  Idiopathic central precocious puberty;  Curative effect