Effects of gonadotropin releasing hormone analogues on idiopathic central precocious puberty in girls

Objective To explore the clinical efficacy of gonadotropin releasing hormone analogues(GnRHa) on idiopathic central precocious puberty(ICPP) in girls.Methods Total 51 girls with ICPP were selected,and GnRHa was given to them for 1~2years.Peak of LH and FSH、estradiol、uterus and ovary volume were observed before and after treatment.And body mass index、bone age、bone age/age、growth velocity、predicted adult height were compare on variable treatment.Results The Peak of LH and FSH were significant lower than those before treatment(P0.01);bone age/age、growth velocity were significant lower than those before treatment(P0.05);predicted adult height was higher than that before treatment,and there was significant difference(P0.05).Conclusion GnRHa could inhibit hypothalamus-hypophysis-gonadal axis to cure ICPP,but there are still unresolved questions about the effects on the actual final adult heigh that future studies will need to address.